发给老马备查:
$ Y' z) D. Q+ E* ], ^7 h滴水察海(69304838) 15:23:23- p8 ?) J# s6 O1 x0 V' |3 U
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱2 @7 g2 A2 a- x7 I3 n" H
吉非替尼和S-1连用的依据6 P, o; w8 t9 x3 I' G1 l
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
% r* s) V( m' T$ ]8 o是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
7 {$ m! H N5 v+ b }7 S这样是不是推理出,耐药后,可以用S-1和培美了?
1 a' y9 z/ A7 F: P7 r结论:1 S* ]& w5 f, J3 ]
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |